Novel Pyrazolo[3,4-b]pyrazines as SHP2 Inhibitors for Treating Cancer
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چکیده
منابع مشابه
SHP2 phosphatase as a novel therapeutic target for melanoma treatment
Melanoma ranks among the most aggressive and deadly human cancers. Although a number of targeted therapies are available, they are effective only in a subset of patients and the emergence of drug resistance often reduces durable responses. Thus there is an urgent need to identify new therapeutic targets and develop more potent pharmacological agents for melanoma treatment. Herein we report that...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2021
ISSN: 1948-5875,1948-5875
DOI: 10.1021/acsmedchemlett.1c00173